Objective To explore the relationship between SIRT1 genetic variation （rs1467568， rs4746720） and microscopic polyangiitis（MPA） in Guangxi population. Methods The SIRT1 polymorphisms of 208 patients with microscopic polyangiitis（MPA）and 211 healthy volunteers were genotyped by multiplex polymerase chain reaction （PCR） and high throughput sequencing. The allele frequencies and genotypes were compared. The linkage disequilibrium，haplotype and genetic model were analyzed. The relationship between different genotypes and clinical symptoms and laboratory biochemical indexes was evaluated. Results The results showed no significant difference between the two groups in genotype，allele frequency，and haplotype of SIRT1 rs1467568 and rs4746720（P > 0.05）. In the age group ≥ 54 years old， the dominant model（OR = 0.50，95%CI：0.27 ~ 0.92， P = 0.026），overdominant model（OR = 0.49，95%CI：0.26 ~ 0.92，P = 0.026）and additive model （OR = 0.57， 95%CI：0.33 ~ 0.99，P = 0.045） of SIRT1 rs1467568 were associated with lower susceptibility to MPA. In rs1467568，MPA patients with GG genotype had higher levels of glutamic pyruvic transaminase （P = 0.012），while in rs4746720， MPA patients with TT and TC genotypes had higher levels of glutamic oxaloacetic transaminase （P = 0.036）. Conclusions In this study， SIRT1 rs4746720 was not related to the susceptibility to MPA in Guangxi population， but rs1467568 may be associated with the susceptibility to MPA in some people （≥ 54 years old） in Guangxi， and rs1467568 and rs4746720 were associated with the levels of glutamic pyruvic transaminase and glutamic oxaloacetic transaminase in patients with MPA.